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SB-743921 hydrochloride

CAS No. : 940929-33-9

MCE 站：SB-743921 hydrochloride

产品活性：SB-743921 hydrochloride 是一种有效的驱动蛋白 (Eg5) 抑制剂，K_i 值为 0.1 nM。

研究领域：Cell Cycle/DNA Damage  |  Cytoskeleton

作用靶点：Kinesin

In Vitro: SB-743921 is a potent inhibitor of Eg5, with a K_i of 0.1 nM. SB-743921 (1 nM) potently inhibits colony forming cell (CFC) formation of chronic myeloid leukemia (CML) primary cells, but exhibits slight inhibitory activities on the colony-forming ability of normal bone marrow progenitors. SB-743921 (1, 3 nM) induces apoptosis of CML primary CD34 + cells, and shows slight effect on normal CD34 + cells. SB-743921 (2 nM) in combination with imatinib displays additive anti-proliferative effect in KCL22 and CML CD34 + cells. Furthermore, SB-743921 overcomes imatinib resistance in CML cells. SB-743921 (0.5 nM, 1 nM, 3 nM) inhibits MEK/ERK and AKT signaling in CML cells.

In Vivo: SB-743921 has good oral bioavailability and pharmacokinetics and induces complete tumor regression in nude mice bearing lung cancer patient xenografts.

相关产品：Drug Repurposing Compound Library Plus  |  Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Anti-Cancer Compound Library  |  Clinical Compound Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  Anti-COVID-19 Compound Library  |  Cytoskeleton Compound Library  |  Anti-Lung Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Kif15-IN-1  |  Monastrol  |  AZ82  |  Paprotrain  |  Litronesib  |  CW-069  |  PF-2771  |  GW406108X  |  Dimethylenastron  |  Kif15-IN-2  |  Eg5 Inhibitor V, trans-24  |  BRD9876

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