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Flavopiridol Hydrochloride

CAS No. : 131740-09-5

MCE 站：Flavopiridol Hydrochloride

产品活性：Flavopiridol Hydrochloride (Alvocidib Hydrochloride) 是一种 CDK 的广谱抑制剂，与 ATP 竞争性地抑制 CDK1，CDK2 和 CDK4 的活性，IC₅₀ 值分别为 30, 170, 100 nM。

研究领域：Cell Cycle/DNA Damage  |  Autophagy  |  Anti-infection

作用靶点：CDK  |  Autophagy  |  HIV

In Vitro: Flavopiridol (2 μM) robustly induces a distinct pattern of ER stress in CLL cells that contributes to cell death through IRE1-mediated activation of ASK1 and possibly downstream caspases. Flavopiridol results in potent upregulation of a number of PRGs in treatments lasting 4-24 h. Flavopiridol has and immediate and long-term effect on the expression of several PRGs. In serum starved cells re-stimulated with serum, flavopiridol also inhibits the expression of these genes, but subsequently, JUNB, GADD45B and EGR1 are upregulated in the presence of flavopiridol.

相关产品：Natural Product Like Compound Library  |  Drug Repurposing Compound Library Plus  |  Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Cell Cycle/DNA Damage Compound Library  |  Kinase Inhibitor Library  |  Anti-Cancer Compound Library  |  Clinical Compound Library  |  Antiviral Compound Library  |  CNS-Penetrant Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  Endoplasmic Reticulum Stress Compound Library  |  Anti-Breast Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Doxorubicin hydrochloride  |  Chloroquine  |  5-Fluorouracil  |  Valproic acid  |  (-)-Epigallocatechin Gallate  |  Ro-3306  |  Shikonin  |  Ivermectin  |  Ebselen  |  Kaempferol  |  Seliciclib  |  Flavopiridol  |  Maraviroc  |  Hydroxyurea  |  Dimethyl fumarate  |  Baicalin  |  Probenecid  |  Ritonavir  |  Fasudil Hydrochloride  |  Lopinavir  |  Betulinic acid  |  Lamivudine  |  Rolipram  |  NVP-2  |  Nelfinavir Mesylate  |  Oltipraz  |  SNS-032  |  Saquinavir

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