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Olmesartan

CAS No. : 144689-24-7

MCE 站：Olmesartan

产品活性：Olmesartan (RNH-6270) 是血管紧张素II受体 (AT1R) 拮抗剂，常用于高血压的相关研究。

研究领域：GPCR/G Protein

作用靶点：Angiotensin Receptor

In Vitro: Olmesartan (0.7-5 mM; 24, 48 and 72?h) inhibits the growth of HeLa cells as a concentration- and time-dependent mode.

In Vivo: Repeated dosing of olmesartan (1 mg/kg, 2 mg/kg, p.o.) dose-dependently decreases mean arterial blood pressure (MAP) in SHR without significant influence on body weight and food intake during 10 weeks. Olmesartan (5 mg/kg/d, p.o.) and Hyd treatments lower systolic blood pressure to the same degree in mice. Olmesartan treatment inhibits cardiac hypertrophy, evaluated by echocardiography, heart weight, cross-sectional area of cardiomyocytes, and gene expression. Olmesartan treatment reverses decreased gene expressions of ACE2 and Mas receptor of Ren-Tg mice and inhibits enhanced NADPH oxidase (Nox)4 expression and reactive oxygen species.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  FDA-Approved Drug Library  |  Drug Repurposing Compound Library  |  Anti-Cardiovascular Disease Compound Library  |  Anti-COVID-19 Compound Library  |  NMPA-Approved Drug Library  |  Orally Active Compound Library  |  Neurotransmitter Receptor Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Drug-Induced Liver Injury (DILI) Compound Library  |  Angiotensin II human  |  Losartan  |  A 779  |  Telmisartan  |  PD 123319 ditrifluoroacetate  |  AVE 0991  |  Valsartan  |  Tranilast  |  YS-49  |  Irbesartan  |  Candesartan  |  CGP-42112  |  Olodanrigan  |  Sparsentan  |  C-Type Natriuretic Peptide (CNP) (1-22), human  |  Azilsartan medoxomil  |  Angiotensin II 5-valine  |  Eprosartan mesylate  |  Angiotensin (1-7) (acetate)  |  Fimasartan  |  Tasosartan  |  Olmesartan medoxomil  |  Angiotensin II (3-8), human TFA  |  Brain Natriuretic Peptide (1-32), rat acetate

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