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GDC-0879

CAS No. : 905281-76-7

MCE 站：GDC-0879

产品活性：GDC-0879 是一种有效的选择性 B-Raf 抑制剂，IC₅₀ 为 0.13 nM。

研究领域：MAPK/ERK Pathway

作用靶点：Raf

In Vitro: GDC-0879 also inhibits pERK with an IC₅₀ of 63 nM. GDC-0879 represents a novel potent and selective B-Raf inhibitor that is being evaluated as a potential antitumor agent. GDC-0879 exhibits potent inhibition of Raf/MEK/ERK signaling pathway in V600E B-Raf mutant cell lines with low cellular pMEK1 inhibition IC₅₀ estimates of 59 and 29 nM in A375 melanoma and Colo205 colorectal carcinoma cells, respectively.

In Vivo: The pharmacokinetic parameters of GDC-0879 after oral administration of 15, 25, 50, 100, and 200 mg/kg in MCT in mice are estimated as follows: k_a=8.20 h^-1, k_e=0.59 h^-1, and apparent volume of distribution=6.19 L/kg.

相关产品：Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Kinase Inhibitor Library  |  MAPK Compound Library  |  Anti-Cancer Compound Library  |  Oxygen Sensing Compound Library  |  Ferroptosis Compound Library  |  Glutamine Metabolism Compound Library  |  Anti-Lung Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Doramapimod  |  GW 5074  |  Ro 5126766  |  AZ 628  |  ZM 336372  |  Agerafenib  |  Raf inhibitor 1  |  AZ304  |  L-779450  |  MCP110  |  Sorafenib (D3)  |  Raf inhibitor 2

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