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Doxercalciferol

CAS No. : 54573-75-0

MCE 站：Doxercalciferol

产品活性：Doxercalciferol 是维生素 D2 类似物，为维生素 D (Vitamin D) 受体激活剂，能够抵抗肾病的进程。

研究领域：Vitamin D Related

作用靶点：VD/VDR

In Vivo: Doxercalciferol (0.083, 0.167 or 0.333 μg/kg, i.p.) elevates serum phosphorus at Week 6 in 5/6 nephrectomized (NX) rats. Doxercalciferol (0.167 and 0.333 μg/kg) also increases serum calcium and Ca × P at Weeks 2 and 6, and enhances increased pulse wave velocity (PWV) at Week 6 in 5/6 nephrectomized (NX) rats. Doxercalciferol blocks PTH from rising at 0.083 μg/kg, and lowers serum PTH to the SHAM level. Doxercalciferol (125 ng/kg, i.p. thrice per week) increases expression of VDR mRNA level and renal expression of TRPV5 in NON mice fed a HF diet. Doxercalciferol also improves proteinuria, prevents loss of podocytes, and accumulation of extracellular matrix proteins in HF diet-induced mice. Doxercalciferol inhibits the expression of profibrotic growth factors (TGF-β, PAI-1, and connective tissue growth factor (CTGF)), and blocks increased expression of the renin-angiotensin-aldosterone system in mice fed a HF diet. Furthermore, Doxercalciferol suppresses macrophage infiltration, decreases NF-κb activity, and preventes expression of proinflammatory cytokine and the increase in renal lipid accumulation in mice fed a HF diet. Doxercalciferol (30 ng/kg, i.p. thrice per week) prevents albuminuria, markedly attenuates podocyte loss and apoptosis, and reduces glomerular fibrosis in streptozotocin-induced diabetic mice.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  Bioactive Compound Library Plus  |  Calcitriol  |  Calcipotriol  |  Vitamin D3  |  Calcifediol  |  Paricalcitol  |  Tacalcitol  |  Seocalcitol  |  Vitamin D2  |  Vitamin D4  |  Alfacalcidol  |  Ercalcidiol  |  Maxacalcitol  |  24, 25-Dihydroxy VD3  |  Eldecalcitol  |  Secalciferol  |  Ercalcitriol  |  3-O-(2-Aminoethyl)-25-hydroxyvitamin D3  |  24, 25-Dihydroxy VD2  |  TEI-9647  |  5,6-trans-Vitamin D3  |  Calcitetrol  |  Falecalcitriol  |  Impurity B of Calcitriol  |  Impurity C of Calcitriol  |  Lexacalcitol  |  VD3-D6

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