MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Taladegib

CAS No. : 1258861-20-9

MCE 站：Taladegib

产品活性：Taladegib (LY2940680) 是一种 smoothened 受体拮抗剂。

研究领域：Stem Cell/Wnt

作用靶点：Smo

In Vitro: Taladegib, a small-molecule antagonist of the smoothened receptor, shows a slight inhibitory effect on cell proliferation without differences between mucin- (IC₅₀: Taladegib=49.8±4.5 μM) and mixed- Cholangiocarcinoma (CCA) (IC₅₀: Taladegib=61.2±21.1 μM). The IC₅₀ for Taladegib inhibition of [³H]MRT-92 binding is right shifted (3- to 100-fold) for the S387A^ECL2, L325F^3.36f, and D473H^6.54f mutants but did not differ from that of WT receptor for the other mutants. The ability of SANT-1 to inhibit [³H]MRT-92 binding to V329F^3.40f and T466F^6.47f mutants is abolished, and it is severely impaired for L325F^3.40f, I408F^5.51f, and M525G^7.45f mutants (4- to 140-fold drop of the IC₅₀), but is not modified for the S387A^ECL2 mutant. Taken together, these data confirm our docking hypothesis that MRT-92-binding mode differs from that of either Taladegib or SANT-1 by simultaneously occupying binding sites 1 and 2.

相关产品：Drug Repurposing Compound Library Plus  |  Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Stem Cell Signaling Compound Library  |  Wnt/Hedgehog/Notch Compound Library  |  Anti-Cancer Compound Library  |  Clinical Compound Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  Differentiation Inducing Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Cyclopamine  |  SAG  |  Purmorphamine  |  20(S)-Hydroxycholesterol  |  Halcinonide  |  Jervine  |  ALLO-2  |  IHR-Cy3

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。