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产品价格:电议      采购度:1587      原产地:美洲
发布时间:2021/7/24 1:15:35 所属地区:上海 上海市
简要描述:
Vilazodone Hydrochloride (EMD 68843 Hydrochloride) 是 5-羟色胺转运体 (SER) 的抑制剂和 5-HT1A 受体的部分激动剂。
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CAS No. : 163521-08-2
MCE 站:Vilazodone Hydrochloride
产品活性:Vilazodone Hydrochloride (EMD 68843 Hydrochloride) 是 5-羟色胺转运体 (SER) 的抑制剂和 5-HT1A 受体的部分激动剂。
研究领域:GPCR/G Protein | Neuronal Signaling
作用靶点:5-HT Receptor | Serotonin Transporter
In Vivo: Administration of 5-HT1A receptor agonists produce a characteristic behavioral syndrome that includes changes in posture, hind limb reduction, head weaving, tremors, forepaw treading, and straub tail. In the rat ultrasonic vocalizations test, stress-induced vocalizations are inhibited by Vilazodone Hydrochloride (EMD 68843 Hydrochloride) (55 mg/kg po) at 120 and 210 min post dose. Vilazodone Hydrochloride (EMD 68843 Hydrochloride) (20-40 mg/kg ip), administered acutely or prophylactically (1 week prior to behavioral testing), attenuated stress induces potentiated startle but has no effect on stress potentiated anxiety response in the elevated plus maze. Interestingly, a lower dose of 10 mg/kg of Vilazodone Hydrochloride (EMD 68843 Hydrochloride) has the opposite effect in the startle response, indicating a somewhat unexplained bidirectional effect, and all doses produce a potentiation of the startle-induced stress response possibly suggestive of an anxiogenic-like response. Vilazodone Hydrochloride (EMD 68843 Hydrochloride) also represents another option for the treatment of MDD.
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更新时间:2024/1/2 10:14:29
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