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CP-466722

CAS No. : 1080622-86-1

MCE 站：CP-466722

产品活性：CP-466722 是一种可逆的 ATM 抑制剂，IC₅₀ 值为 4.1 μM，但对 PI3K，PIKK 家族蛋白没有作用。

研究领域：Cell Cycle/DNA Damage  |  PI3K/Akt/mTOR

作用靶点：ATM/ATR

In Vitro: CP-466722 (CP466722, 6-10 μM) inhibits IR-induced ATM kinase activity, and the inhibition can be rapidly and completely reversed. CP466722 (6, 10 μM) inhibits p53 induction and ATM-dependent phosphorylation in mouse cells, but CP466722 fails to inhibit ATR activity and ATR-dependent phosphorylation of Chk1. CP466722 (6 μM) disrupts ATM-dependent cell cycle checkpoints in cells. CP466722 (1 ?M) completely inhibits ATM-dependent phosphorylation in MCF7 cells. CP466722 (10 ?M) reduces pKAP1 phosphorylation in MCF7 cells, with an IC₅₀ of 0.41 ?M. CP466722 (10 ?M) inhibits both pATM and pKAP1 signals. CP-466722 (CP466722, 5-50 μM) inhibits proliferation of SKBr-3 cancer cells more strongly than MCF-7 cancer cells. CP466722 (10 ?M) also slightly increases proportions of MCF-7 and SKBr-3 cells in the G1 phase after treatment for 48 hours.

相关产品：Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Kinase Inhibitor Library  |  PI3K/Akt/mTOR Compound Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Oxygen Sensing Compound Library  |  Glycolysis Compound Library  |  Cytoskeleton Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  AZ20  |  CGK733  |  AZ32  |  ETP-46464  |  Garcinone C  |  Ro 90-7501  |  NU6027

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