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3-Aminobenzamide

CAS No. : 3544-24-9

MCE 站：3-Aminobenzamide

产品活性：3-Aminobenzamide (PARP-IN-1) 是一种有效的 PARP 抑制剂，在 CHO 细胞中，对 PARP 的 IC₅₀ 值约为 50 nM。

研究领域：Cell Cycle/DNA Damage  |  Epigenetics

作用靶点：PARP

In Vitro: 3-Aminobenzamide (PARP-IN-1) (>1 μM) causes more than 95% inhibition of PARP activity without significant cellular toxicity. INO-1001 significantly sensitizes CHO cells by blocking most of the DNA repair occurring between radiation fractions.?3-Aminobenzamide significantly improves endothelial function by enhancing the acetylcholine-induced, endothelium-dependent, nitric oxide mediated vasorelaxation after exposure with 400 μM H₂O₂.

In Vivo: In a db/db (Leprdb/db) mouse model, 3-Aminobenzamide ameliorates diabetes-induced albumin excretion and mesangial expansion, and also decreases diabetes-induced podocyte depletion. 3-Aminobenzamide (1.6 mg/kg via intracerebral injection) prevents NAD⁺ depletion and improves water maze performance after controlled cortical impact (CCI) in mice.

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