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SB 216763

CAS No. : 280744-09-4

MCE 站：SB 216763

产品活性：SB 216763是有效，选择性和ATP竞争性的 GSK-3 抑制剂，抑制GSK-3α和GSK-3β的 IC₅₀ 为34.3 nM。

研究领域：PI3K/Akt/mTOR  |  Stem Cell/Wnt  |  Autophagy

作用靶点：GSK-3  |  Autophagy

In Vitro: SB-216763 (10-20 ?M) induces β-catenin mediated-transcription in a dose-dependent manner in HEK293 cells. SB-216763 (10, 15 and 20 ?M) can maintain mESCs with a pluripotent-like morphology in long-term culture. SB-216763 (10 ?M) can maintain J1 mESCs in a pluripotent state for more than a month. SB-216763 inhibits GSK-3 with IC₅₀ of 34 nM. SB-216763 is equally effective at inhibiting human GSK-3α and GSK-3β.

In Vivo: SB216763 (20 mg/kg, i.v.) significantly improves the survival of BLM-treated mice. Mice randomized to receive BLM plus SB216763 shows a noteworthy reduction, compared with BLM-treated mice. SB216763 (20 mg/kg, i.v.) reduces the magnitude of BLM-induced alveolitis. SB 216763 (0.2 mg/kg, i.v.) with either 17β-E₁₀₀ or Geni₁₀₀ reverses the ceiling effect because these agents significantly reduce infarct size when the rabbits' hearts are submitted to 30-min CAO.

相关产品：Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  PI3K/Akt/mTOR Compound Library  |  Stem Cell Signaling Compound Library  |  Wnt/Hedgehog/Notch Compound Library  |  Anti-Cancer Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Reprogramming Compound Library  |  Oxygen Sensing Compound Library  |  Glycolysis Compound Library  |  Cytoskeleton Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  CHIR-99021  |  AR-A014418  |  TDZD-8  |  Kenpaullone  |  GSK 3 Inhibitor IX  |  Cromolyn sodium  |  R547  |  SB 415286  |  IM-12  |  Indirubin-3'-monoxime  |  1-Azakenpaullone  |  AZD2858  |  BIO-acetoxime  |  CP21R7  |  Bikinin  |  GNF4877  |  GSK-3β inhibitor 1  |  hSMG-1 inhibitor 11j  |  TCS 21311  |  BIP-135  |  5-Iodo-indirubin-3'-monoxime  |  Alsterpaullone  |  GSK-3 inhibitor 1  |  GSK-3β inhibitor 2  |  Manzamine A hydrochloride  |  2B-(SP)  |  GSK3 Substrate, α, β subunit

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