型号:
产品价格:电议      采购度:1612      原产地:美洲
发布时间:2021/7/24 1:42:32 所属地区:上海 上海市
简要描述:
KU-57788 (NU7441) 是一种高效的选择性 DNA-PK 抑制剂,IC50 为 14 nM。 KU-57788 是 NHEJ 通路抑制剂。KU-57788 还抑制 PI3K 和 mTOR,IC50 分别为 和 μM。
标签:NU7441
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CAS No. : 503468-95-9
MCE 站:KU-57788
产品活性:KU-57788 (NU7441) 是一种高效的选择性 DNA-PK 抑制剂,IC50 为 14 nM。 KU-57788 是 NHEJ 通路抑制剂。KU-57788 还抑制 PI3K 和 mTOR,IC50 分别为 5.0 和 1.7 μM。
研究领域:Cell Cycle/DNA Damage | PI3K/Akt/mTOR
作用靶点:DNA-PK | CRISPR/Cas9
In Vitro: NU7441 (0.5 to 10 ?M) inhibits the growth of liver cancer HepG2 cells dose- and time-dependently. NU7441 reduces pDNA-PKcs (S2056) protein expression in liver cancer cells. Furthermore, double treatment of NU7441 and 60Coγ IR affects DNA damage repair. NU7441 is solvent-exposed in BRD4, this inhibitor can be classified as a Type I BRD inhibitor. NU7441 reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.
In Vivo: KU-57788 (0.5 to 10 ?M) inhibits the growth of liver cancer HepG2 cells dose- and time-dependently. KU-57788 reduces pDNA-PKcs (S2056) protein expression in liver cancer cells. Furthermore, double treatment of KU-57788 and 60Coγ IR affects DNA damage repair. KU-57788 weakly inhibits BRD4 and BRDT with IC50s of 1 μM and 3.5 μM, respectively. KU-57788 is solvent-exposed in BRD4, this inhibitor can be classified as a Type I BRD inhibitor. KU-57788 reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.
相关产品:Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Kinase Inhibitor Library | PI3K/Akt/mTOR Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Oxygen Sensing Compound Library | Glycolysis Compound Library | Cytoskeleton Compound Library | Anti-Pancreatic Cancer Compound Library | LY294002 | Brefeldin A | Nocodazole | PI-103 | Zidovudine | RS-1 | SCR7 pyrazine | LTURM34 | L755507 | YU238259 | Compound 401 | AMA-37
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更新时间:2024/1/2 10:14:29
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