MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

VER-82576

CAS No. : 847559-80-2

MCE 站：VER-82576

产品活性：VER-82576 (NVP-BEP800) 是一种有效的，可口服的，选择性的 Hsp90 抑制剂，对 Hsp90β 的 IC₅₀ 值为 58 nM；VER-82576 同时可较弱地抑制 Grp94 和 Trap-1 的活性，IC₅₀ 值分别为 4.1 和 5.5 μM。

研究领域：Cell Cycle/DNA Damage  |  Metabolic Enzyme/Protease

作用靶点：HSP

In Vitro: VER-82576 (NVP-BEP800) is a potent and selective Hsp90 inhibitor, with an IC₅₀ of 58 nM for Hsp90β and is >70-fold selective against Grp94 and Trap-1, with IC₅₀s of 4.1 ± 1.1 and 5.5 ± 0.48 μM. VER-82576 potently inhibits the proliferation of tumor cells, with GI₅₀s ranging from 38 nM in A375 cells to 1050 nM in PC3 cells, with an average GI₅₀ of 245 nM. VER-82576 (250-1250 nM) depletes client proteins in human cancer cell lines in vitro. VER-82576 (NVP-BEP800; 200 nM) shows no significant effect on the ionizing radiation (IR) dose-response curves of A549 cells, and is less toxic to SNB19 cells. VER-82576 in combination with IR results in more severe DNA damage in both A549 and SNB19 cell lines than each treatment alone and also protracts the kinetics of DNA damage repair in SNB19 cells. VER-82576 (NVP-BEP800; 0.05, 0.1 or 0.2 μM) dose-dependently decreases the viability and induces apoptosis of glioblastoma cells. VER-82576 (0.2 μM) suppresses the expression of IKKβ protein but does not alter the levels of IKKβ mRNA in T98G cells. VER-82576 (0.2 μM) suppresses the expression of heat shock protein 70.

In Vivo: VER-82576 (NVP-BEP800; 15 or 30 mg/kg, p.o.) shows antitumor activities in A375 cancer xenografts and BT-474 xenograft-bearing mice.

相关产品：Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Metabolism/Protease Compound Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Endoplasmic Reticulum Stress Compound Library  |  Pyroptosis Compound Library  |  Cytoskeleton Compound Library  |  Orally Active Compound Library  |  Tamoxifen  |  Tanespimycin  |  Geldanamycin  |  Palmitic acid  |  Rocaglamide  |  VER-155008  |  Arimoclomol maleate  |  PU-WS13  |  Pifithrin-μ  |  MKT-077  |  KNK437  |  KRIBB11  |  Paeoniflorin  |  Retaspimycin Hydrochloride  |  TRC051384  |  ML346  |  Radicicol  |  Teprenone  |  AMP-PCP disodium  |  Ethoxyquin  |  Cucurbitacin D  |  Falcarinol  |  Aminohexylgeldanamycin  |  HS-27  |  3-Phenyltoxoflavin  |  Alvespimycin  |  Calenduloside E  |  Geldanamycin-FITC  |  Kongensin A

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。