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Quetiapine hemifumarate

CAS No. : 111974-72-2

MCE 站：Quetiapine hemifumarate

产品活性：Quetiapine hemifumarate 是一种 5-HT 受体激动剂，对人 5-HT1A 的 pEC₅₀ 值为 4.77。Quetiapine hemifumarate 是多巴胺受体 (dopamine receptor) 拮抗剂，对人 D2 的 pIC₅₀ 值为 6.33。Quetiapine hemifumarate 对人 D2，HT1A，5-HT2A，5-HT2C 受体具有中高等亲和力，pK_i 值为 7.25，5.74，7.54，5.55。具有抗抑郁和抗焦虑作用。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：5-HT Receptor  |  Dopamine Receptor

In Vitro: Quetiapine (<100?μM; 24?hours) has no significant effect on cell viabilities.
Quetiapine (10?μM) inhibits NO release, which increased by LPS (0.1-100 ng/mL) in concentration-dependent manner.
Quetiapine (10?μM) also inhibits TNF-α synthesis.

In Vivo: Quetiapine (10?mg/kg/day; ingested) can alleviate the recruitment and activation of microglia and promote myelin repair in Cuprizone (CPZ)-induced chronic mouse model of demyelination.

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