型号:
产品价格:电议      采购度:1602      原产地:美洲
发布时间:2021/7/24 2:20:43 所属地区:上海 上海市
简要描述:
Dronedarone Hydrochloride 是一种非碘化胺碘酮衍生物, 可抑制Na+, K+ and Ca2+的电流。
标签:Multaq
产品详情
MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 141625-93-6
MCE 站:Dronedarone Hydrochloride
产品活性:Dronedarone Hydrochloride 是一种非碘化胺碘酮衍生物, 可抑制Na+, K+ and Ca2+的电流。
研究领域:Membrane Transporter/Ion Channel | Autophagy
作用靶点:Potassium Channel | Autophagy
In Vitro: Dronedarone (SR-33589) is a multichannel blocker for atrial fibrillation . It is a potent inhibitor of the acetylcholine-activated K+ current from atrial and sinoatrial nodal tissue, and inhibits the rapid delayed rectifier more potently than slow and inward rectifier K+ currents and inhibits L-type calcium current. Under whole-cell patch clamp, it blocks IKr (IC50=3 μM) and ICa-L (IC50=0.18 μM). The effects on ICa-L are use- and frequency-dependent. Dronedarone inhibits current carried by human ether-a-go-go gene (HERG)-expressing oocytes (analagous to IKr) with an IC50 of 9 μM. In guinea pig ventricular myocytes, dronedarone exhibits a state dependent inhibition of the fast Na+ channel current with an IC50 of 0.7±0.1 μM, when the holding potential is ?80 mV.
In Vivo: Dronedarone (Hydrochloride) reduces significantly the incidence of ventricular fibrillation (VF) from 80 to 30% (p < 0.05) at 3 mg/kg i.v. and eliminated VF and mortality at 10 mg/kg i.v. . Dronedarone inhibited carotid artery thrombus formation in vivo. Thrombin- and collagen-induced platelet aggregation is impaired indronedarone-treated mice (P\0.05), and expression ofplasminogen activator inhibitor-1 (PAI1), an inhibitor of the fibrinolytic system, is reduced in the arterial wall.
相关产品:Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Membrane Transporter/Ion Channel Compound Library | FDA-Approved Drug Library | Autophagy Compound Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | Anti-Cardiovascular Disease Compound Library | Orally Active Compound Library | FDA Approved & Pharmacopeial Drug Library | Drug-Induced Liver Injury (DILI) Compound Library | Nigericin sodium salt | BAPTA-AM | Rosuvastatin Calcium | SKF-96365 hydrochloride | Glibenclamide | SCH-23390 hydrochloride | Tetrandrine | Amiodarone hydrochloride | TRAM-34 | Ifenprodil tartrate | Minoxidil | Diazoxide | 20(S)-Ginsenoside Rg3 | Senicapoc | Tannic acid | DCPIB | Astemizole | Ketanserin | Quinine | E-4031 | Terfenadine | Hydrochlorothiazide | GW9508 | Daurisoline | Nicorandil | Dofetilide | Pinacidil monohydrate | ML277 | Tolbutamide | Almitrine mesylate
品牌介绍:
• MCE (MedChemExpress) 拥有数百种全球独家化合物,我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物;
• 10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果;
• 专业团队跟踪*新的制药及生命科学研究进展,为您提供全球*新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。
更新时间:2024/1/2 10:14:29
留言咨询
温馨提示
1.遵守中华人民共和国有关法律、法规,尊重网上道德,承担一切因您的行为而直接或间接引起的法律责任。
2.请您真实的反映产品的情况,不要捏造、诬蔑、造谣。如对产品有任何疑问,也可以留言咨询。
3.未经本站同意,任何人不得利用本留言簿发布个人或团体的具有广告性质的信息或类似言论。
相关新闻
相关产品