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Belumosudil

CAS No. : 911417-87-3

MCE 站：Belumosudil

产品活性：Belumosudil (KD025) 是一种选择性的 ROCK2 抑制剂，对 ROCK2 和 ROCK1 的 IC₅₀ 值分别为 105 nM 和 24 ?M。具有抗纤维化特性。

研究领域：Cell Cycle/DNA Damage  |  Stem Cell/Wnt  |  Cytoskeleton  |  TGF-beta/Smad

作用靶点：ROCK

In Vitro: Belumosudil (SLx-2119; 40 ?M) induces significant down-regulations of Tsp-1 and CTGF mRNA levels in PASMC. The microarray hybridized with aRNA from HMVEC treated with Belumosudil, shows a 5-times higher background than the other arrays.

In Vivo: Belumosudil (KD-025; 100, 200 or 300?mg/kg, i.p.) dose-dependently reduces infarct volume after transient middle cerebral artery occlusion. Belumosudil is at least as efficacious in aged, diabetic or female mice, as in normal adult males.

相关产品：Drug Repurposing Compound Library Plus  |  Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Immunology/Inflammation Compound Library  |  Kinase Inhibitor Library  |  Stem Cell Signaling Compound Library  |  TGF-beta/Smad Compound Library  |  Clinical Compound Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  Reprogramming Compound Library  |  Diabetes Related Compound Library  |  Anti-COVID-19 Compound Library  |  Cytoskeleton Compound Library  |  Y-27632 dihydrochloride  |  Chroman 1  |  Fasudil Hydrochloride  |  Narciclasine  |  Ripasudil  |  GSK429286A  |  Y-33075  |  CMPD101  |  H-1152 dihydrochloride  |  Hydroxyfasudil  |  BDP5290  |  SR-3677  |  SB-772077B dihydrochloride  |  Pentanoic acid  |  ZINC00881524  |  Verosudil  |  ROCK-IN-1  |  ROCK2-IN-2

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