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Lapatinib ditosylate

CAS No. : 388082-77-7

MCE 站：Lapatinib ditosylate

产品活性：Lapatinib ditosylate (GW572016 ditosylate) 是一种 ErbB-2 和 EGFR 酪氨酸激酶结构域的有效抑制剂，对纯化的 EGFR 和 ErbB-2 的 IC₅₀ 值分别为 10.2 和 9.8 nM。

研究领域：JAK/STAT Signaling  |  Protein Tyrosine Kinase/RTK  |  Autophagy  |  Apoptosis

作用靶点：EGFR  |  Autophagy  |  Ferroptosis

In Vitro: Lapatinib (GW2016; 0.03-10 ?M; 6 hours; BT474 and HN5 cells) treatment inhibits receptor autophosphorylation of EGFR and ErbB-2 in a dose-responsive manner. Phosphorylation of serine 473 of AKT was inhibited by GW2016 in a dose-dependent manner.
Lapatinib (GW2016; 72 hours; HN5, A-43, BT474, N87, and CaLu-3 cells) treatment has a selective inhibition of the proliferation of human tumor cell lines.
Lapatinib (GW2016; 1-10 ?M; 72 hours; HN5 cells) treatment results in induces G1 arrest.

In Vivo: Lapatinib (GW2016; 30-100 mg/kg; oral administration; twice daily; for 21 days; CD-1 nude female mice) treatment inhibits tumor xenograft growth of the HN5 cells in a dose-responsive manner at 30 and 100 mg/kg, with complete inhibition of tumor growth at the higher dose.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Apoptosis Compound Library  |  Immunology/Inflammation Compound Library  |  JAK/STAT Compound Library  |  Kinase Inhibitor Library  |  Protein Tyrosine Kinase Compound Library  |  FDA-Approved Drug Library  |  Anti-Cancer Compound Library  |  CNS-Penetrant Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  Differentiation Inducing Compound Library  |  Ferroptosis Compound Library  |  Anti-COVID-19 Compound Library  |  Orally Active Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Anti-Hepatitis C Virus Compound Library  |  Anti-Breast Cancer Compound Library  |  Anti-Lung Cancer Compound Library  |  Drug-Induced Liver Injury (DILI) Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Targeted Therapy Drug Library   |  Erastin  |  Ferrostatin-1  |  Cisplatin  |  Cycloheximide  |  RSL3  |  Acetylcysteine  |  Deferoxamine mesylate  |  SP600125  |  Necrostatin-1  |  Gefitinib  |  Trastuzumab  |  Rosiglitazone  |  Erlotinib  |  SB 202190  |  Cetuximab  |  AG490  |  Curcumin  |  Hemin  |  (-)-Epigallocatechin Gallate  |  TBHQ  |  Simvastatin  |  Bardoxolone methyl  |  U-73122  |  Pifithrin-α hydrobromide  |  Lovastatin  |  Trolox  |  Eprenetapopt  |  Genistein  |  L-Glutathione reduced  |  Pioglitazone

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