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RO-9187

CAS No. : 876708-03-1

MCE 站：RO-9187

产品活性：RO-9187是高效的HCV病毒复制抑制剂，IC₅₀值为171 nM。

研究领域：Anti-infection

作用靶点：HCV

In Vitro: RO-9187 is excellent substrates for deoxycytidine kinase and is phosphorylated with efficiencies up to 3-fold higher than deoxycytidine. RO-9187 inhibits RNA synthesis by HCV polymerases from either HCV genotypes 1a and 1b or containing S96T or S282T point mutations with similar potencies, suggesting no cross-resistance with either R1479 (4′-azidocytidine) or 2′-C-methyl nucleosides. The formation of RO-9187-TP increased in a time- and dose-dependent manner. The maximal triphosphate concentration at 24 h is 87 pmol/106 cells with half-maximal triphosphate formation achieved at 12 μM RO-9187.

In Vivo: Plasma exposures of RO-9187 in rats increase in a dose-dependent manner between 10 and 2000 mg/kg after oral dosing. Plasma concentrations of 1.4 and 26 μM (390 and 7454 ng/mL) are achieved in rats and dogs at the 10 mg/kg dose level, respectively. Plasma concentrations up to 57 μM are achieved in rats dosed with 2000 mg/kg/day.

相关产品：Natural Product Like Compound Library  |  Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Antiviral Compound Library  |  Nucleotide Compound Library  |  Anti-Hepatitis C Virus Compound Library  |  Resiquimod  |  Honokiol  |  Ribavirin  |  Deferiprone  |  U18666A  |  AG-1478  |  EIDD-1931  |  Artemisinin  |  NIM811  |  Alisporivir  |  Myriocin  |  Mizoribine  |  Merimepodib  |  NHC-triphosphate  |  PSI-7409  |  Peretinoin  |  BLT-1  |  Celgosivir hydrochloride  |  Clemizole hydrochloride  |  Gentiopicroside  |  NM107  |  ITX5061  |  Deapioplatycodin D  |  KIN1408  |  Oglufanide  |  PSI-6130  |  RO8191  |  Taribavirin hydrochloride

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