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Selisistat

CAS No. : 49843-98-3

MCE 站：Selisistat

产品活性：Selisistat (EX-527) 是一种有效，选择性的 SIRT1 抑制剂，IC₅₀ 为 98 nM。

研究领域：Cell Cycle/DNA Damage  |  Epigenetics

作用靶点：Sirtuin

In Vitro: Selisistat (EX-527) is an inhibitor of SIRT1 enzymatic activity (IC₅₀, 98 nM), identified in a high-throughput screen using bacterially expressed human SIRT1. Selisistat (EX-527) inhibits SIRT1 in a concentration-dependent manner with an IC₅₀ of 38 nM, in agreement with the activity on bacterially expressed SIRT1. Selisistat (EX-527) has much lower potency against SIRT2 (IC₅₀, 19.6 μM) or SIRT3 (IC₅₀, 48.7 μM) but does not inhibit class I/II HDAC activity at concentrations up to 100 μM. Selisistat (EX-527) exerts an inhibitory effect on SIRT1 activity without affecting SIRT1 expression on both mRNA and protein levels.

In Vivo: Selisistat (EX-527) abolishes Resveratrol (RSV)-induced attenuation of microvascular inflammation in ob/ob septic mice. Finally, ob/ob mice in Sepsis+RSV group has significantly increased 7-day survival vs. Sepsis+Vehicle group.

相关产品：Drug Repurposing Compound Library Plus  |  Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Epigenetics Compound Library  |  Immunology/Inflammation Compound Library  |  Histone Modification Research Compound Library  |  Anti-Cancer Compound Library  |  Clinical Compound Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  Antioxidants Compound Library  |  Reprogramming Compound Library  |  Oxygen Sensing Compound Library  |  Glutamine Metabolism Compound Library  |  Resveratrol  |  Nicotinamide  |  Nicotinamide riboside chloride  |  3-TYP  |  Suramin sodium salt  |  OSS_128167  |  Fisetin  |  UBCS039  |  Sirtinol  |  CAY10602  |  AGK2  |  AK-7  |  SIRT5 inhibitor 1  |  Cambinol  |  MC3482  |  Ganoderic acid D  |  PROTAC Sirt2 Degrader-1  |  SRT 2183  |  Dihydrocoumarin  |  Ginkgolide C  |  Inauhzin  |  SIRT-IN-3  |  JFD00244  |  Gardenia yellow  |  Agrimol B  |  Selisistat R-enantiomer  |  Sirtuin modulator 1  |  Ophiopogonin D'  |  Scopolin  |  SirReal2

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