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Atorvastatin hemicalcium salt

CAS No. : 134523-03-8

MCE 站：Atorvastatin hemicalcium salt

产品活性：Atorvastatin hemicalcium salt (CI-981) 是一种口服活性的 3-羟基-3-甲基戊二酰辅酶A (HMG-CoA) 还原酶抑制剂，具有有效降低血脂的能力。Atorvastatin hemicalcium salt 以 IC₅₀分别为 0.39 μM 和 2.39 μM 来抑制人 SV-SMC 增殖和侵袭。

研究领域：Metabolic Enzyme/Protease  |  Autophagy  |  Apoptosis

作用靶点：HMG-CoA Reductase (HMGCR)  |  Autophagy  |  Ferroptosis

In Vitro: Atorvastatin treatment decreases apoptosis of myocardial cells by down-regulating GRP78, caspase-12 and CHOP expression in myocardial cells after myocardial infarction, and the endoplasmic reticulum (ER) stress is activated in response to heart failure and angiotensin II (Ang II) stimulation.

In Vivo: Atorvastatin (20-30 mg/kg; oral gavage; once a day; for 28 days; ApoE^?/? mice) treatment significantly reduces endoplasmic reticulum (ER) stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE-/- mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β are all remarkably inhibited after Atorvastatin treatment.

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