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Idarubicin hydrochloride

CAS No. : 57852-57-0

MCE 站：Idarubicin hydrochloride

产品活性：Idarubicin hydrochloride 是一种蒽环类抗白血病药物。 它抑制 拓扑异构酶 II，干扰 DNA 复制和 RNA 转录。Idarubicin hydrochloride 还抑制细菌和酵母菌的生长。

研究领域：Cell Cycle/DNA Damage  |  Anti-infection  |  Autophagy

作用靶点：Topoisomerase  |  Bacterial  |  Fungal  |  Autophagy

In Vitro: The IC₅₀ of idarubicin is 3.3±0.4 ng/mL on MCF-7 monolayers and 7.9±1.1 ng/mL in multicellular spheroids. Idarubicin has shown a greater cytotoxicity than daunorubicin or doxorubicin in various in vitro systems. This has been attributed to a better ability of idarubicin to induce the formation of topoisomerase II -mediated DNA breaks.Idarubicin is about 57.5-fold and 25-fold more active than doxorubicin and epirubicin, respectively. Idarubicin produces a concentration-dependent reduction in cell growth, with an IC₅₀ value of approximately 0.01 μM. Idarubicin produced a concentration-dependent inhibition of DNA synthesis.

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