MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Quetiapine

CAS No. : 111974-69-7

MCE 站：Quetiapine

产品活性：Quetiapine (ICI204636) 是一种 5-HT 受体激动剂，对人 5-HT1A 的 pEC₅₀ 值为 4.77。Quetiapine 是多巴胺受体 (dopamine receptor) 拮抗剂，对人 D2 的 pIC₅₀ 值为 6.33。Quetiapine 对人 D2，HT1A，5-HT2A，5-HT2C 受体具有中高等亲和力，pK_i 值为 7.25，5.74，7.54，5.55。具有抗抑郁和抗焦虑作用。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：5-HT Receptor  |  Dopamine Receptor

In Vitro: Quetiapine (<100?μM; 24?hours) has no significant effect on cell viabilities.
Quetiapine (10?μM) inhibits NO release, which increased by LPS (0.1-100 ng/mL) in concentration-dependent manner.
Quetiapine (10?μM) also inhibits TNF-α synthesis.

In Vivo: Quetiapine (10?mg/kg/day; ingested) can alleviate the recruitment and activation of microglia and promote myelin repair in Cuprizone (CPZ)-induced chronic mouse model of demyelination.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Neuronal Signaling Compound Library  |  FDA-Approved Drug Library  |  CNS-Penetrant Compound Library  |  Drug Repurposing Compound Library  |  Anti-COVID-19 Compound Library  |  NMPA-Approved Drug Library  |  Orally Active Compound Library  |  Neurotransmitter Receptor Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Anti-Alzheimer’s Disease Compound Library  |  Drug-Induced Liver Injury (DILI) Compound Library  |  Clozapine N-oxide  |  MPTP hydrochloride  |  Oxidopamine hydrobromide  |  Bromocriptine mesylate  |  Harmine  |  SCH-23390 hydrochloride  |  Pimozide  |  L-DOPA  |  Puerarin  |  Olanzapine  |  Haloperidol  |  GTS-21 dihydrochloride  |  Thioridazine hydrochloride  |  Risperidone  |  SKF 38393 hydrochloride  |  Cabergoline  |  SB-269970 hydrochloride  |  Fluphenazine dihydrochloride  |  Dihydroergotamine mesylate  |  Amitriptyline hydrochloride  |  Aripiprazole  |  Ketanserin  |  WAY-100635 Maleate  |  Buspirone hydrochloride  |  Cisapride  |  Methiothepin mesylate  |  Trazodone hydrochloride

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。