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Tegafur

CAS No. : 17902-23-7

MCE 站：Tegafur

产品活性：Tegafur (FT 207; NSC 148958) 是抗癌剂5-FU的前药。

研究领域：Cell Cycle/DNA Damage

作用靶点：Nucleoside Antimetabolite/Analog

In Vitro: Tegafur is bioactivated to 5-FU by liver microsomal cytochrome P450 enzymes. 5-FU is subsequently converted into its active metabolites 5-fluoro-deoxyuridine-monophosphate (FdUMP) and 5-fluorouridine-triphosphate (FUTP) intracellularly; these metabolites inhibit the enzyme thymidylate synthase and intercalate into RNA, resulting in decreased thymidine synthesis, reduced DNA synthesis, disrupted RNA function, and tumor cell cytotoxicity.

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