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(R)-(-)-Ibuprofen

CAS No. : 51146-57-7

MCE 站：(R)-(-)-Ibuprofen

产品活性：(R)-(-)-Ibuprofen 是 Ibuprofen 的 R 型异构体，对 COX 无作用，可以抑制 NF-κB 的活化；(R)-(-)-Ibuprofen 具有抗炎和镇痛的作用。

研究领域：NF-κB

作用靶点：NF-κB

In Vitro: (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, with no inhibitory effect on COX, but is involved in pathways of lipid metabolism and is incorporated into triglycerides along with endogenous fatty acids. (R)-(-)-Ibuprofen (1 μM) significantly reduces NF-κB activation and completely prevents NF-κB induction at 10 μM. (R)-(-)-Ibuprofen inhibits NF-κB luciferase activity with an IC₅₀ of 121.8 μM, weaker than that of S(+)-ibuprofen (IC₅₀, 61.7 μM). Furthermore, (R)-(-)-Ibuprofen (10 mM) has no effect on HSF.

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