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BAM7

CAS No. : 331244-89-4

MCE 站：BAM7

产品活性：BAM7 是一种直接的选择性 BAX 激活剂，IC₅₀ 为 3.3 μM。

研究领域：Apoptosis

作用靶点：Bcl-2 Family

In Vitro: BAM7 is selective for the BH3-binding site on BAX. BAM7 activates BAX and BAX-dependent cell death. Whereas treatment with BAX or BAM7 alone has no effect on the liposomes, the combination of BAM7 and BAX yields dose-responsive liposomal release of entrapped fluorophore. BAM7 dose- and time-responsively impairs the viability of Bak^-/- MEFs that exclusively express BAX but has no effect on Bak^-/- MEFs that contain BAK but lack BAX. In contrast, standard proapoptotic stimuli such as serum withdrawal, Staurosporine and Etoposide induces an equivalent apoptotic response in Bax^-/- and Bak^-/- MEFs. As further evidence of BAM7 specificity of action, (i) BAM7 does not affect the viability of Bax^-/- Bak^-/- MEFs; (ii) ANA-BAM16, which does not bind or activate BAX, has no effect on Bak^-/- MEFs; and (iii) BAM7 selectively induces cell death of Bax^-/- Bak^-/- MEFs reconstituted with wild-type BAX but not BAXK21E , which bears the mutation that abrogates BAM7 binding.

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