型号：
产品价格：电议 采购度：1629 原产地：美洲
发布时间：2021/7/24 5:00:48 所属地区：上海 上海市
简要描述：
PJ34 hydrochloride 是 PARP1/2 的抑制剂，IC50 值分别为 110 nM 和 86 nM。
标签：pj
产品详情
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
CAS No. : 344458-15-7
MCE 站：PJ34 hydrochloride
产品活性：PJ34 hydrochloride 是 PARP1/2 的抑制剂，IC50 值分别为 110 nM 和 86 nM。
研究领域：Cell Cycle/DNA Damage | Epigenetics
作用靶点：PARP
In Vitro: PJ34 inhibits the PARP enzyme activity with an IC50 of 110±1.9 nM. To compare the neuroprotective properties of other PARP inhibitors in PC12 cells, PJ34 is evaluated using by LDH assay. PJ34 treatment also significantly and concentration dependently attenuates cell death at a concentration ranging from 10-7 to 10-5 M.
In Vivo: To compare the potency and efficacy with other PARP inhibitors, PJ34 is evaluated at the doses of 3.2 and 10 mg/kg, respectively. PJ34 at the dose of 3.2 mg/kg significantly reduces cortical damage by 33%; however, 10 mg/kg dosing shows reversed effect (17% reduction). PJ34 (25 mg/kg) reduces the levels of TNF-α mRNA in ischemic animals by 70% and these values in treated mice do not differ from that of sham or naive animals. Treatment of ischemic mice with PJ34 reduces the level of E-selectin mRNA by 81% and that of ICAM-1 mRNA by 54%, compared to vehicle-treated ischemic mice.
相关产品：Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Epigenetics Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Neuroprotective Compound Library | Anti-Breast Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | XAV-939 | Rucaparib | PJ34 | 3-Aminobenzamide | G007-LK | Dehydrocorydaline chloride | AG14361 | Iniparib | AZD-2461 | BGP-15 | Fucosterol | JW 55 | EB-47 dihydrochloride | UPF 1069 | AZ6102 | iRucaparib-AP6 | ME0328 | MN-64 | 5,?7,?4'-?Trimethoxyflavone | Benzamide | GeA-69 | Paris saponin VII | PARP14 inhibitor H10 | BYK204165 | NU1025 | Oroxin A | 2-Methylquinazolin-4-ol
品牌介绍:
• MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
• 10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
• 设有专业的实验中心和严格的质控、验证体系；
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
• 产品的生物活性多经各国客户实验验证；
• Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
• 专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
• 与世界各大制药公司及知名科研机构建立了长期的合作。
更新时间：2024/1/2 10:14:41
留言咨询
温馨提示
1.遵守中华人民共和国有关法律、法规，尊重网上道德，承担一切因您的行为而直接或间接引起的法律责任。
2.请您真实的反映产品的情况,不要捏造、诬蔑、造谣。如对产品有任何疑问,也可以留言咨询。
3.未经本站同意，任何人不得利用本留言簿发布个人或团体的具有广告性质的信息或类似言论。
相关新闻
相关产品
