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UPF 1069

CAS No. : 1048371-03-4

MCE 站：UPF 1069

产品活性：UPF 1069 是一种 PARP 抑制剂，对 PARP-1 和 PARP-2 的 IC₅₀ 值分别为 8 和 0.3 μM。

研究领域：Cell Cycle/DNA Damage  |  Epigenetics

作用靶点：PARP

In Vitro: UPF 1069 (Compound 55) is a PARP inhibitor, with IC₅₀s of 8 and 0.3 μM for PARP-1 and PARP-2, respectively. UPF 1069 (1 ?M) reduces the residual PARP activity by approximately 80% of PARP-1-deficient fibroblasts, but only slightly inhibits the enzymic activity in wild-type fibroblasts. UPF 1069 (0.1-1 ?M) markedly enhances CA1 hippocampal damage. UPF 1069 (10 ?M) also exacerbates oxygen-glucose deprivation (OGD) damage in organotypic hippocampal slices. However, UPF 1069 alleviates the damage cuased by OGD in mixed cortical cell cultures, shows a potent neuroprotective activity both at a concentration (1 ?M) selectively acting on PARP-2 and at a concentration (10 ?M) inhibiting both PARP-1 and PARP-2 activities.

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