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Capsazepine

CAS No. : 138977-28-3

MCE 站：Capsazepine

产品活性：Capsazepine是感觉神经元兴奋毒素的合成类似物，和TRPV1 受体拮抗剂，其中IC₅₀ 为562 nM。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling  |  Apoptosis

作用靶点：TRP Channel  |  Apoptosis

In Vitro: Capsazepine (50 μM) optimally enhances the upregulation of (death receptors) DRs without affecting cell viability HCT116 cells. Capsazepine (30-50 μM) induces ROS generation and ROS mediate Capsazepine-induced DR5 upregulation in HCT116 cells. Capsazepine (1-100 μM, 45 min preincubation) inhibits the evoked CGRP-LI release. Capsazepine (3-100 μM) prevents low pH- and capsaicin-induced CGRP-LI release from rat soleus muscle at concentrations which do not affect the release evoked by KCl. Capsazepine (3-100 μM, without 10 μM) produces a nonspecific inhibitory effect on CGRP-LI release from peripheral endings of the capsaicin-sensitive primary afferent neurone.

In Vivo: Capsazepine (15 mg/kg, s.c.) prevents the increase in respiratory system resistance and decreases the increase in tissue damping during endotoxemia. Capsazepine attenuates lung injury evidenced by reduction on collapsed area of the lung parenchyma induced by LPS.

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