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AZD1208

CAS No. : 1204144-28-4

MCE 站：AZD1208

产品活性：AZD1208 是一种有效的，具有口服活性的，具有高度选择性的 PIM 抑制剂。

研究领域：JAK/STAT Signaling  |  Autophagy  |  Apoptosis

作用靶点：Pim  |  Autophagy  |  Apoptosis

In Vitro: AZD1208 shows good antiproliferative activity in a megakaryoblastic leukemia cell line, MOLM-16, with GI₅₀ values less than 100 nM. AZD1208 (10 μM) inhibits the growth of Ramos cells, and at 1 μM, strongly inhibits PIM kinases in all cell at 1 μM. AZD1208 induces apoptosis, and PIM2 knockdown is mainly associated with an alteration of the cell cycle. The combination of AZD1208 and AZD2014 rapidly activates AMPKα, a negative regulator of translation machinery through mTORC1/2 signaling in AML cells; profoundly inhibits AKT and 4EBP1 activation; and suppresses polysome formation.

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