MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Ro3280

CAS No. : 1062243-51-9

MCE 站：Ro3280

产品活性：Ro3280 是一种有效的，高度选择性的 PLK1 抑制剂，IC₅₀ 和 K_d 值分别为 3 nM 和 0.09 nM，对 PLK2 和 PLK3 几乎没作用。

研究领域：Cell Cycle/DNA Damage

作用靶点：Polo-like Kinase (PLK)

In Vitro: Ro3280 (RO3280) inhibits PLK1 activity in NB4 and K562 cells, with an IC₅₀s of 13.45 nM and 301 nM, respectively. RO3280 shows inhibitory activities against the growth of six leukemia cells, with IC₅₀s of 186 nM, 175 nM, 74 nM, 797 nM, 120 nM and 162 nM for U937, HL60, NB4, K562, MV4-11 and CCRF cell lines, respectively. RO3280 also suppresses the growth of primary ALL and AML cells, with IC₅₀s of 35.49-110.76 nM, and 52.80-147.50 nM, respectively. RO3280 (50 or 100 nM) induces apoptosis and cell cycle disorder in acute leukemia cells. Ro3280 shows potent activity in H82, H69, A549 lung cancer cell lines with EC₅₀s of 6 nM, 7 nM and 82 nM. Ro3280 also inhibits several other cancer cell lines, with low concentration. RO3280 is cytotoxic to 5637 and T24 human bladder cancer cells, with IC₅₀s of appr 100 nM.

In Vivo: Ro3280 (RO3280, 40 mg/kg, i.v.) inhibits 72% tumor growth in a mouse xenograft model implanted with HT-29 colorectal cancer cells, and when dosed more frequently, RO3280 completely suppresses the tumor growth. RO3280 (30 mg/kg, once every 5 days, i.p.) shows significant anti-bladder cancer activities in a nude mouse model.

相关产品：Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Kinase Inhibitor Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Anti-Lung Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Wortmannin  |  GW843682X  |  LFM-A13  |  Poloxin  |  HMN-214  |  SBE13 Hydrochloride  |  TC-S 7005  |  Poloxime  |  Cyclapolin 9

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。