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Entecavir monohydrate

CAS No. : 209216-23-9

MCE 站：Entecavir monohydrate

产品活性：Entecavir monohydrate (BMS200475 monohydrate; SQ34676 monohydrate) 是有选择且有效地HBV抑制剂。在HepG2细胞中的EC₅₀值为3.75 nM。

研究领域：Anti-infection

作用靶点：HBV

In Vitro: Entecavir monohydrate (BMS200475 monohydrate; SQ34676 monohydrate) has a EC₅₀ of 3.75 nM against HBV. It is incorporated into the protein primer of HBV and subsequently inhibits the priming step of the reverse transcriptase. The antiviral activity of BMS-200475 is significantly less against the other RNA and DNA viruses.
Entecavir monohydrate is more readily phosphorylated to its active metabolites than other deoxyguanosine analogs (penciclovir, ganciclovir, lobucavir, and aciclovir) or lamivudine. The intracellular half-life of entecavir is 15 h.

In Vivo: Daily oral treatment with Entecavir monohydrate at doses ranging from 0.02 to 0.5 mg/kg of body weight for 1 to 3 months effectively reduces the level of woodchuck hepatitis virus (WHV) viremia in chronically infected woodchucks.

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