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Cetirizine dihydrochloride

CAS No. : 83881-52-1

MCE 站：Cetirizine dihydrochloride

产品活性：Cetirizine dihydrochloride 是羟嗪的羧化代谢物，是第二代抗组胺药。Cetirizine dihydrochloride 是一种特异的、口服有效的、H1 受体 的长效拮抗剂。Cetirizine dihydrochloride 标记抗过敏特性，抑制过敏反应期间嗜酸性粒细胞趋化。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Immunology/Inflammation

作用靶点：Histamine Receptor

In Vitro: Cetirizine (>5 μM) at higher concentrations can reduce the release of GM-CSF and IL-8 from A549 cells stimulated with IL-1β. Cetirizine exerts anti-inflammatory effects beyond histamine H1-receptor antagonist^[2].

In Vivo: Cetirizine (20 mg/kg, mice, orally) exerts its anti-inflammatory effects by inhibiting MIF as well as IL-8 production in mice immunized and challenged with ragweed pollen^[3].

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Immunology/Inflammation Compound Library  |  Neuronal Signaling Compound Library  |  FDA-Approved Drug Library  |  Drug Repurposing Compound Library  |  Endocrinology Compound Library  |  Anti-COVID-19 Compound Library  |  NMPA-Approved Drug Library  |  Pyroptosis Compound Library  |  Orally Active Compound Library  |  Neurotransmitter Receptor Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Drug-Induced Liver Injury (DILI) Compound Library  |  Histamine  |  Clemastine fumarate  |  Amitriptyline hydrochloride  |  Astemizole  |  Fexofenadine hydrochloride  |  Osthole  |  Terfenadine  |  Famotidine  |  Diphenhydramine hydrochloride  |  Levocetirizine dihydrochloride  |  Perphenazine  |  Loratadine  |  Cimetidine  |  Chlorprothixene  |  Lodoxamide  |  Pitolisant hydrochloride  |  Rupatadine Fumarate  |  Desloratadine  |  Latrepirdine dihydrochloride  |  Mianserin hydrochloride  |  Mirtazapine  |  Ebastine  |  Azelastine hydrochloride  |  Ritanserin  |  Chlorpheniramine maleate  |  Mepyramine maleate  |  Cinnarizine  |  Ranitidine hydrochloride  |  Clemizole hydrochloride  |  Ketotifen fumarate

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