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Duloxetine hydrochloride

CAS No. : 136434-34-9

MCE 站：Duloxetine hydrochloride

产品活性：Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) 是 5-羟色胺-去甲肾上腺素重吸收 (serotonin-norepinephrine reuptake) 抑制剂 (SNRI)，K_i 为 4.6 nM，可作用于广泛性焦虑症。

研究领域：Neuronal Signaling

作用靶点：Serotonin Transporter

In Vitro: Duloxetine ((S)-Duloxetine hydrochloride) (sold under the brand names Cymbalta, Ariclaim, Xeristar, Yentreve, Duzela, Dulane) is a serotonin-norepinephrine reuptake inhibitor(SNRI) manufactured and marketed by Eli Lilly. It is prescribed for major depressive disorder and generalized anxiety disorder (GAD). Duloxetine also has approval for use in osteoarthiritis and musculoskeletal pain. Duloxetine failed the US approval for stress urinary incontinence amidst concerns over liver toxicity and suicidal events; however, it was approved for this indication in Europe, where it is recommended as an add-on medication in stress urinary incontinence instead of surgery. It can also relieve the symptoms of painful peripheral neuropathy, particularly diabetic neuropathy, and it is used to control the symptoms of fibromyalgia. The main uses of duloxetine are in major depressive disorder, general anxiety disorder, stress urinary incontinence, painful peripheral neuropathy,fibromyalgia, and chronic musculoskeletal pain associated with osteoarthritis and chronic lower back pain. It is being studied for various other indications.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Neuronal Signaling Compound Library  |  FDA-Approved Drug Library  |  Drug Repurposing Compound Library  |  Diabetes Related Compound Library  |  Anti-COVID-19 Compound Library  |  NMPA-Approved Drug Library  |  Orally Active Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Drug-Induced Liver Injury (DILI) Compound Library  |  Paroxetine hydrochloride  |  Fluvoxamine maleate  |  Imipramine hydrochloride  |  Sertraline hydrochloride  |  Desipramine hydrochloride  |  Amitriptyline hydrochloride  |  Escitalopram oxalate  |  Clomipramine hydrochloride  |  Citalopram hydrobromide  |  Vilazodone  |  Dapoxetine hydrochloride  |  Venlafaxine hydrochloride  |  Milnacipran hydrochloride  |  Amitifadine hydrochloride  |  Azaphen dihydrochloride monohydrate  |  Cinchonidine  |  (S)-Venlafaxine  |  (±)-Duloxetine hydrochloride

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