MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

CC-90011 Methylbenzenesulfonate

CAS No. : 2097523-57-2

MCE 站：CC-90011 Methylbenzenesulfonate

产品活性：CC-90011 Methylbenzenesulfonate 是一种有效的，选择性的，可逆的和具有口服活性的赖氨酸特异性脱甲基酶-1 (LSD1) 抑制剂，IC₅₀ 为 0.25 nM。CC-90011 Methylbenzenesulfonate 对 LSD2，MOA-A 和 MAO-B 的酶抑制作用较小。CC-90011 Methylbenzenesulfonate 诱导急性髓细胞性白血病 (AML)和小细胞肺癌 (SCLC) 细胞分化，并具有有效的抗癌活性。

研究领域：Epigenetics

作用靶点：Histone Demethylase

In Vitro: CC-90011 (Compound 11) shows potent induction of on-target cellular differentiation marker CD11b in THP-1 cell line with an EC₅₀ of 7 nM, antiproliferative activity in AML kasumi-1 cells with an EC₅₀ of 2 nM.
Suppression of GRP is observed with treatment of CC-90011 (4 days) in a dose-dependent manner and at pharmacologically useful concentrations (EC₅₀=3 nM, H209 and 4 nM, H1417). CC-90011 (12 days) treatment of SCLC cells results in potent antiproliferative activity (EC₅₀=6 nM, H1417) that correlated with GRP suppression.

In Vivo: CC-90011 (5 mg/kg; oral administration; daily; for 30 days; for 30 days) treatment inhibits tumor growth in patient-derived xenograft SCLC models.
CC-90011 (once a day; for 4 days) treatment results in robust downregulation of GRP mRNA levels at 2.5 mg/kg and maximum suppression of GRP at 5 mg/kg in a SCLC human tumor xenograft (H1417) mice.
After i.v. administration, CC-90011 (Compound 11; 5 mg/kg) has systemic clearance of 32.4 mL/min/kg, elimination half-life of 2 h, and a high volume of distribution of 7.5 L/kg. CC-90011 (Compound 11; 5 mg/kg) is readily absorbed after oral administration with an AUC_0-24h of 1.8 μM·h, C/sub>max of 0.36 μM, and oral bioavailability of 32%.

相关产品：GSK-J4  |  JIB-04  |  IOX1  |  Corin  |  Tranylcypromine hemisulfate  |  KDOAM-25 citrate  |  NCGC00244536  |  L-2-Hydroxyglutaric acid disodium  |  Daminozide  |  PBIT  |  AS8351  |  Procaine  |  CBB1007 trihydrochloride  |  α-Hydroxyglutaric acid  |  (rel)-Tranylcypromine D5 hydrochloride  |  KDM2A/7A-IN-1

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。