MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Bemesetron

CAS No. : 40796-97-2

MCE 站：Bemesetron

产品活性：Bemesetron (MDL 72222) 是一种选择性 5-HT₃ 受体拮抗剂，IC₅₀ 为 0.33 nM 。具有神经保护作用。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：5-HT Receptor

In Vitro: Blockade of 5-HT₃ receptor with Bemesetron (MDL7222) reduces hydrogen peroxide-induced neurotoxicity in cultured rat cortical cells. Bemesetron (0.01, 0.1 and 1 μM, 15 hours) and Y25130 (0.05, 0.5 and 5 μM) concentration-dependently reduce the H₂O₂-induced decrease of MTT reduction showing 74.9±2.4 and 79.0 ±2.5% with 1 μM and 5 μM, respectively, which are maximal effects.
Pretreatment (20 minutes) with Bemesetron (1 μM), Y25130 (5 μM) or MK-801 (10 μM) significantly, but not completely, inhibits the H₂O₂-induced elevation of [Ca²⁺]_c.
Bemesetron (1 μM, 15 hours) significantly blocks the H₂O₂-induced increase of caspase-3 immunoreactivity.

In Vivo: Bemesetron (0.1, 1 and 10 mg/kg; i.p.) is used in male adult albino mice. The lowest dose do not cause any significant change in catalepsy. However, Bemesetron (1 mg/kg) causes a significant reduction of catalepsy (from 90 min after Haloperidol), while 10 mg/kg significantly potentiates the phenomenon (from 60 min after Haloperidol). The maximum inhibition of catalepsy (about 75%) occurs at 120 min, and the maximum potentiation (about 4.5-times the control value) occurs at 60 min after Haloperidol.

相关产品：Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Neuronal Signaling Compound Library  |  Neurotransmitter Receptor Compound Library  |  Anti-Alzheimer’s Disease Compound Library  |  Neuroprotective Compound Library  |  Harmine  |  SCH-23390 hydrochloride  |  Puerarin  |  Olanzapine  |  GTS-21 dihydrochloride  |  Thioridazine hydrochloride  |  Risperidone  |  SB-269970 hydrochloride  |  Dihydroergotamine mesylate  |  Amitriptyline hydrochloride  |  Aripiprazole  |  Ketanserin  |  WAY-100635 Maleate  |  Buspirone hydrochloride  |  Cisapride  |  Methiothepin mesylate  |  Trazodone hydrochloride  |  Pindolol  |  Quetiapine  |  Lumateperone tosylate  |  Perphenazine  |  8-OH-DPAT  |  Levomepromazine  |  SB-224289 hydrochloride  |  Volinanserin  |  Ziprasidone  |  Paliperidone  |  Sertindole  |  Alprenolol hydrochloride  |  Asenapine maleate

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。