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CGS 15943

CAS No. : 104615-18-1

MCE 站：CGS 15943

产品活性：CGS 15943 是 adenosine receptor 腺苷受体的非黄嘌呤拮抗剂，具有口服活性。接受人重组 A1，A2A，A2B和 A3 受体转染的 CHO 细胞中，K_i 值分别为 3.5、4.2、16 和 50 nM。

研究领域：GPCR/G Protein  |  PI3K/Akt/mTOR

作用靶点：Adenosine Receptor  |  PI3K

In Vitro: CGS 15943 inhibits the kinase activity of the class IB PI3K isoform p110γ with an IC₅₀ of 1.1 μM and shows slight inhibition on p110δ with an IC₅₀ of 8.47 μM.
CGS 15943 (0-20 μM; 72 hours) inhibits growth of HLF and SK-Hep-1 cells, as well as HepG2 and PLC-PRF-5 cells.
CGS 15943 (0-20 μM; 24 hours) reduces the phosphorylation of Akt at its residues Ser473 and Thr308 in HLF and Sk-Hep-1 cells.

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