型号:
产品价格:电议      采购度:1621      原产地:美洲
发布时间:2021/7/24 16:44:29 所属地区:上海 上海市
简要描述:
Go6976 是蛋白激酶C (PKC) 的一个抑制剂,其 IC50 值为20 nM。
产品详情
MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 136194-77-9
MCE 站:Go6976
产品活性:Go6976 是蛋白激酶C (PKC) 的一个抑制剂,其 IC50 值为20 nM。
研究领域:Epigenetics | TGF-beta/Smad | Anti-infection
作用靶点:PKC | Influenza Virus
In Vitro: Go6976 is a potent inhibitor of PKC in vitro (IC50 is 20 nM. This compound is structurally related to staurosporine, which is the most potent PKC inhibitor. UCN-01 is originally identified as a PKC inhibitor. Surprisingly, Go6976 is found to abrogate S and G2 arrest. Dose-response studies reveal that 30 nM Go6976 is sufficient to cause abrogation of S-phase arrest in 6 h and abrogation of G2 arrest followed by lethal mitosis in 24 h. Incubation of cells with 100 nM Go6976 is sufficient to cause complete abrogation of S and G2 arrest at 6 and 24 h, respectively, which is only slightly less potent than in bovine serum. Incubation of cells with UCN-01 or Go6976 alone do not decrease viability compared with control at the concentrations used. Incubation of cells with 5 ng/mL SN38 result in cytostasis, and addition of 50 nM UCN-01 or 100 nM Go6976 to arrested MDA-MB-231 cells cause a dramatic decrease in viable cell number by 96 h.
相关产品:Bioactive Compound Library Plus | Anti-Infection Compound Library | Epigenetics Compound Library | Kinase Inhibitor Library | TGF-beta/Smad Compound Library | Anti-Cancer Compound Library | Antiviral Compound Library | Reprogramming Compound Library | Oxygen Sensing Compound Library | Cytoskeleton Compound Library | Phorbol 12-myristate 13-acetate | Acetylcysteine | Staurosporine | U0126-EtOH | Tunicamycin | Vadimezan | Ionomycin | Favipiravir | Curcumin | Camptothecin | Aprotinin | Go 6983 | Midostaurin | Oseltamivir acid | Geldanamycin | Emricasan | Rifampicin | Bisindolylmaleimide I | Fasudil Hydrochloride | Mitoxantrone | Baicalein | Mycophenolic acid | AG-1478 | AEBSF hydrochloride | α-Vitamin E | Nitazoxanide | GSK 650394 | Umifenovir hydrochloride | Rottlerin
品牌介绍:
• MCE (MedChemExpress) 拥有数百种全球独家化合物,我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物;
• 10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果;
• 专业团队跟踪*新的制药及生命科学研究进展,为您提供全球*新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。
更新时间:2024/1/2 10:15:06
留言咨询
温馨提示
1.遵守中华人民共和国有关法律、法规,尊重网上道德,承担一切因您的行为而直接或间接引起的法律责任。
2.请您真实的反映产品的情况,不要捏造、诬蔑、造谣。如对产品有任何疑问,也可以留言咨询。
3.未经本站同意,任何人不得利用本留言簿发布个人或团体的具有广告性质的信息或类似言论。
相关新闻
相关产品