MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

LY367385

CAS No. : 198419-91-9

MCE 站：LY367385

产品活性：LY367385 是一种高效且选择性的 mGluR1a 拮抗剂，抑制喹喹啉诱导的磷酸肌醇水解的 IC₅₀ 值为 8.8 μM，而对 mGlu5a 的 IC₅₀ 值大于 100 μM。LY367385 具有神经保护，抗惊厥和抗癫痫作用。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：mGluR

In Vitro: LY367385 combined with N-methyl-D-aspartate (NMDA) during the toxic pulse attenuates neuronal degeneration in a concentration-dependent fashion, with a maximal reduction of NMDA toxicity ranging from 40 to 60%. LY367385 shows greater efficacy than LY367366 and neither of these compounds influenced neuronal viability per se. LY367385 shows potent neuroprotective effects, with causing a 50% reduction in (S)-3,5-Dihydroxyphenylglycine (DHPG) potentiation at a concentration of 10 nM. Under experimental conditions at higher concentrations of antagonist, LY367385 a completely antagonized the amplification of NMDA toxicity by DHPG.

In Vivo: LY367385 has been administered intracerebroventricularly (i.c.v.) to DBA/2 mice and lethargic mice (lh/lh), and focally into the inferior colliculus of genetically epilepsy prone rats (GEPR). In DBA/2 mice, LY367385 produces a rapid, transient suppression of sound-induced clonic seizures ED50 = 12 nM, i.c.v., 5 min). In lethargic mice, LY367385 significantly reduces the incidence of spontaneous spike and wave discharges on the electroencephalogram, from 30 to >150 min after the administration of LY367385, 250 nM, i.c.v.
In genetically epilepsy prone rats, LY367385 reduces sound-induced clonic seizures. LY367385, 160 nM bilaterally, fully suppresses clonic seizures after 2-4 h.

相关产品：L-Glutamine  |  LY341495  |  DHPG  |  Eglumegad  |  MPEP Hydrochloride  |  MTEP hydrochloride  |  Xanthurenic acid  |  Ro 67-7476  |  VU0650786  |  Lu AF21934  |  LY404039  |  trans-ACPD  |  (RS)-MCPG  |  CPPHA  |  L-Cysteinesulfinic acid monohydrate  |  CDPPB  |  PHCCC  |  CTEP  |  E4CPG  |  FITM  |  JNJ-46778212  |  LY2794193  |  VU0364770  |  CHPG  |  Fenobam  |  L-AP4  |  O-Phospho-L-serine  |  VU 0357121

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。