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Adenosine amine congener

CAS No. : 96760-69-9

MCE 站：Adenosine amine congener

产品活性：Adenosine amine congener (ADAC) 是一种选择性的 A1 腺苷受体 (A1 adenosine receptor) 激动剂，可以改善噪音和顺铂引起的耳蜗损伤。Adenosine amine congener 还具有神经保护作用。

研究领域：GPCR/G Protein

作用靶点：Adenosine Receptor

In Vitro: Adenosine amine congener can reduce oxidative stress in the noise-exposed cochlea, leading to protection of sensory hair cells. Adenosine amine congener also can reduce cisplatin-induced apoptosis in cochlear tissues, particularly in sensory hair cells and strial marginal cells. The mechanisms of otoprotection by Adenosine amine congener include inhibition of glutamate release via presynaptic A1 receptors and inhibition of voltage-gated Ca²⁺ channels, which can prevent activation of apoptotic and necrotic cell death pathways.

In Vivo: Adenosine amine congener (25-300?μg/kg/day; intraperitoneal injection; daily; for 5 days; male Wistar rats) treatment is most effective in the first 24 hours after noise exposure at doses >50?μg/kg, providing up to 21?dB protection. Adenosine amine congener mitigates noise-induced hearing loss in a dose- and time-dependent manner.

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