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(R)-Terazosin

CAS No. : 109351-34-0

MCE 站：(R)-Terazosin

产品活性：(R)-Terazosin 是 Terazosin 的活性 R 型对应体, 是一种有效的 α1-肾上腺素受体拮抗剂，对 α1a，α1b 和 α1d-肾上腺素受体的 K_i 值分别为 6.51 nM，1.01 nM 和 1.97 nM。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Adrenergic Receptor

In Vitro: (R)-Terazosin is low affinity for α2a, α2B and α2c-adrenoceptor with K_i values of 3.85 μM, 0.33 μM and 0.37 μM, respectively.
(R)-Terazosin may prove to be a useful probe in understanding the functional role of subtypes of adrenoceptors in various tissues. Because it is a weaker antagonist at α2B sites than its enantiomer, it may be possible to use (R)-Terazosin to differentiate between pharmacological effects mediated by subtypes of α2-adrenoceptors in animal studies.

In Vivo: (R)-Terazosin shows antagonism of at rat atrial α2B receptor with a pEC₃₀ of 5.69. (R)-Terazosin shows antagonism of at rat vas deferens α1A and α2A receptor with pA₂ values of 7.5 and 5.31, respectively.

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