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Fluphenazine decanoate

CAS No. : 5002-47-1

MCE 站：Fluphenazine decanoate

产品活性：Fluphenazine decanoate 是一种长效的吩噻嗪抗精神病药，用于精神分裂症的研究。Fluphenazine decanoate 也是一种高度且连续的多巴胺 D₂ 受体阻滞剂。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Dopamine Receptor

In Vivo: Six female Persian onagers (Equus hemionus onager) are treated with Fluphenazine decanoate (0.1?mg/kg IM) or saline control. Urinary cortisol, progesterone, estrogen metabolites and behavior are monitored, and follicular dynamics are examined using ultrasonography until ovulation. Onagers demonstrate significantly lower cortisol concentrations when treated with Fluphenazine decanoate (6.61?ng/mg creatinine) compared to saline (9.73?ng/mg creatinine). There are no differences in peak estrogen or progesterone concentrations between the two groups, and all animals ovulate within the expected time frame following Fluphenazine decanoate treatment. However, some onagers exhibit only minor reductions in cortisol secretion and one treated female demonstrates a suppressed luteal progesterone peak, indicating a possible reproductive cost to Fluphenazine decanoate administration.

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