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Fulvene-5

CAS No. : 1075723-01-1

MCE 站：Fulvene-5

产品活性：Fulvene-5 是一种有效的 NADPH 氧化酶 4 (NOX4) 抑制剂，具有抗氧化特性。Fulvene-5 是一种活性氧 (ROS) 修饰剂和有效的辐射防护剂，并具有抗肿瘤活性。

研究领域：Metabolic Enzyme/Protease  |  NF-κB  |  Immunology/Inflammation

作用靶点：NADPH Oxidase  |  Reactive Oxygen Species

In Vitro: Fulvene-5 (10??M; 1 hour) facilitates the reversal of HCT116 TP53 wild type (WT) and HCT116 isogenic TP53 null mutant (Mut) cell cultures adaptive responses from pro-survival to radio-sensitization and vice versa. These changes are accompanied by corresponding reversals in the translocation of survivin to the nuclei of TP53 WT and to the cytoplasm of TP53 Mut cells. The potential role of NOX4 in the expression of the survivin-associated adaptive response is investigated by transfecting HCT116 cells with NOX4 siRNA oligomers to inhibit NOX4 expression. Under these conditions NOX4 expression is inhibited by about 50%.
Fulvene-5 (0.5-1.0 μM) treatment decreases the expression of Ang2, delta-like ligand 4 (DLL4), placental growth factor (PLGF), and Nrarp in a dose-dependent manner in bEnd.3 cells.

In Vivo: Fulvene-5 (120 mg/kg/d; intraperitoneal injection; daily; for 2 weeks; nude mice) treatment potently inhibits hemangioma growth in mice.

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