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GSK1702934A

CAS No. : 924377-85-5

MCE 站：GSK1702934A

产品活性：GSK1702934A是一种选择性的 TRPC3 激动剂。GSK1702934A 通过激活 TRPC3 调节心脏收缩力和心律失常。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：TRP Channel

In Vitro: GSK1702934A is able to induce TRPC3/6-currents in HEK293 cells transduced with recombinant human TRPC3/6 with an EC₅₀ of 0.08 mM and 0.44 mM, respectively.
GSK1702934A induces a transient, non-selective conductance and prolonged action potentials in TRPC3-overexpressing myocytes but not in wild-type myocytes.
GSK1702934A substantially promotes NCX currents in TRPC3-overexpressing myocytes.

In Vivo: GSK1702934A (0.3-3 mg/kg; i.v.) transiently increases blood pressure by 15 ~ 35 mmHg in conscious Sprague Dawley rats.

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