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FKBP12 PROTAC RC32

CAS No. : 2375555-66-9

MCE 站：FKBP12 PROTAC RC32

产品活性：FKBP12 PROTAC RC32 (RC32) 是基于 PROTAC 的有效 FKBP12 降解剂。FKBP12 PROTAC RC32 包含雷帕霉素 (Rapamycin；HY-10219) 和 E3 泛素连接酶配体 (Pomalidomide；HY-10984)。

研究领域：PROTAC  |  Autophagy  |  Apoptosis  |  Immunology/Inflammation

作用靶点：PROTAC  |  FKBP

In Vitro: FKBP12 PROTAC RC32 (RC32; 0.1-1000 nM; for 12?hours) results in 50% protein degradation (DC₅₀) of ~0.3?nM after only 12?hours of treatment.

In Vivo: RC32 (RC32; i.p.; 30?mg/kg; twice a day; 1 day) degrades the FKBP12 protein in most of the organs of treated mice, except for the brain after only 1 day of treatment in mice.
RC32 (orally; 60?mg/kg; twice a day; for 1 day) significantly degrades FKBP12 in mice.
RC32 (i.p.; 8?mg/kg; twice a day; for 2 days) efficiently degrades the FKBP12 protein in most of the organs examined in Bama pigs (20?kg) .
RC32 (i.p.; 8?mg/kg; twice a day; for 3 days) efficiently degrades FKBP12 in the heart, liver, kidney, spleen, lung, and stomach of rhesus monkeys.

相关产品：Bioactive Compound Library Plus  |  Apoptosis Compound Library  |  Immunology/Inflammation Compound Library  |  Anti-Cancer Compound Library  |  Autophagy Compound Library  |  Macrocyclic Compound Library  |  Rapamycin  |  Everolimus  |  Tacrolimus  |  Rimiducid  |  AP20187  |  Shield-1  |  Ascomycin  |  LC-2  |  AP1867  |  ACBI1  |  CP-10  |  PROTAC Bcl2 degrader-1  |  SLF  |  PROTAC SGK3 degrader-1  |  BI-3663  |  PROTAC Sirt2 Degrader-1  |  PROTAC CDK9 Degrader-1  |  PROTAC RIPK degrader-2  |  PROTAC BRD9 Degrader-1  |  PROTAC ERα Degrader-2  |  BSJ-03-204  |  GMB-475  |  Homo-PROTAC cereblon degrader 1  |  PROTAC AR Degrader-4 TFA  |  PROTAC BET degrader-3  |  PROTAC FKBP Degrader-3  |  GPI-1046  |  PROTAC BET degrader-2  |  PROTAC RAR Degrader-1

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