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Norethindrone

CAS No. : 68-22-4

MCE 站：Norethindrone

产品活性：Norethindrone (Norethisterone) 一种孕激素，用于研究子宫内膜异位症、由激素水平异常引起的子宫出血和继发性闭经。

研究领域：Others

作用靶点：Progesterone Receptor

In Vivo: Norethindrone acetate could be a cost-effective alternative with relatively mild side effects in the treatment of symptomatic endometriosis. Subjects treated with norethindrone acetate obtain dysmenorrhea and noncyclic pelvic pain relief. Norethindrone acetate alone is a well-tolerated, effective option to manage pain and bleeding for all stages of endometriosis. Post-Norethindrone acetate bleeding scores are improved regardless of prior hormonal regimen, and post-Norethindrone acetate pain scores improved in all patients except for those previously prescribed GnRH-agonist plus add-back. Norethindrone acetate shows low acute toxicity in experimental animals and is consistent with the lack of toxicity seen in humans. Administration of norethindrone acetate alone to rodents at several multiples of the human dose results in no treatment related mortality, hematological changes, behavioral changes, or organ pathology. Norethindrone acetate administration leads to significant and proportional reductions of the concentrations of triglycerides, cholesterol and phospholipids of plasma lipoproteins of density <1.006 of rats fed a high carbohydrate diet. Norethindrone acetate (0.1 mM) also significantly inhibits the incorporation of both palmitate and glycerol into triglycerides of isolated hepatocytes from fed rats.

相关产品：Covalent Screening Library Plus  |  Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  FDA-Approved Drug Library  |  Drug Repurposing Compound Library  |  Covalent Screening Library  |  Lipid Compound Library  |  Endocrinology Compound Library  |  Orally Active Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Drug-Induced Liver Injury (DILI) Compound Library  |  Mifepristone  |  Progesterone  |  Medroxyprogesterone acetate  |  Cridanimod  |  Dydrogesterone  |  Dienogest  |  Tanaproget  |  Megestrol acetate  |  Ulipristal acetate  |  17α-Hydroxyprogesterone  |  Altrenogest  |  Nomegestrol acetate  |  Drospirenone  |  Desogestrel  |  Norethindrone acetate  |  Norethisterone enanthate  |  Chlormadinone acetate  |  Ethynodiol diacetate  |  Medroxyprogesterone acetate D3  |  Nestoron  |  Asoprisnil  |  Estradiol dipropionate  |  Gestodene  |  Melengestrol acetate  |  Norgestimate  |  Tibolone  |  Gestonorone Capronate

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