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Detomidine carboxylic acid

CAS No. : 115664-39-6

MCE 站：Detomidine carboxylic acid

产品活性：Detomidine carboxylic acid 是 Detomidine 的主要尿代谢产物。Detomidine 是一种合成的 α2-肾上腺素能 (α2-adrenergic) 激动剂，也是一种动物镇痛镇静剂。Detomidine 还具有心脏和呼吸作用以及抗利尿作用。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Adrenergic Receptor

In Vivo: Horse urine is investigated for metabolites following the oral administration of the large animal analgesic sedative Detomidine to two stallions and intravenous administration of [³H]-Detomidine to a mare. Detomidine carboxylic acid and hydroxydetomidine glucuronic acid conjugate are identified in the urine after the oral doses. About half of the radioactivity of [³H]-Detomidine is excreted in the urine in 12 h after the i.v. dose (80 μg/kg). Most of the excretion occurred between 5 and 12 h in contrast to urine output which is highest 2-5 h after the dosing. The major radioactive metabolite in the urine is Detomidine carboxylic acid. Detomidine carboxylic acid comprises more than two thirds of the total metabolites in all the urine fractions collected.

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