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SM-276001

CAS No. : 473930-22-2

MCE 站：SM-276001

产品活性：SM-276001 是一种有效的选择性 TLR7 激动剂，可以诱导抗肿瘤免疫反应。SM-276001 是一种具有口服活性的干扰素 (IFN) 诱导剂。

研究领域：Immunology/Inflammation

作用靶点：Toll-like Receptor (TLR)  |  IFNAR

In Vitro: SM-276001 (1 nM-10 μM) dose-dependently activates NF-κB through human TLR7.

In Vivo: SM-276001 demonstrates potent IFN-inducing activity at a dose of 0.1 mg/kg by oral administration in mice.
Oral administration of SM-276001, leads to the induction of an inflammatory cytokine and chemokine milieu and to the activation of a diverse population of immune effector cells including T and B lymphocytes, NK and NKT cells.
SM-276001 (3 mg/kg PO biweekly) significantly inhibits tumor growth in the Renca renal cell cancer and CT26 colorectal models.
SM-276001 (orally; 0.1, 1 or 10 mg/kg) leads to the activation of a diverse population of spleen-resident immune effector cells in Balb/c and C57BL/6J mice. When administered at 1 mg/kg or greater, the plasma concentration of SM-276001 exceeds the MEC of 30 nM.

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