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Adenosine 5′-diphosphoribose sodium

CAS No. : 68414-18-6

MCE 站：Adenosine 5′-diphosphoribose sodium

产品活性：Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) 是一种烟酰胺腺嘌呤核苷酸 (NAD⁺) 的代谢产物，也是一种*有效和*主要的细胞内 Ca²⁺ 渗透性阳离子 TRPM2 通道激活剂，还可以增强自噬 (autophagy)。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling  |  Autophagy

作用靶点：TRP Channel  |  Autophagy

In Vitro: In mouse embryonic fibroblasts (MEFs), H₂O₂ treatment demonstrates that the activation of poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) produced Adenosine 5′-diphosphoribose (ADP ribose), which is an activating signal for TRPM2 channels, thereby promoting Ca²⁺ elevation through extracellular Ca²⁺ influx and (or) lysosomal Ca²⁺ release. This process eventually activates early or late autophagy in response to different degrees of oxidative stress.
TRPM2 channels are activated by binding of Adenosine 5′-diphosphoribose (ADP ribose) to the intracellular NUDT9-homology (NUDT9-H) domain unique to TRPM2 and located at its C terminus. In addition to ADPR, intracellular Ca²⁺ is an essential coactivator: TRPM2 channels open only in the combined presence of both ligands.

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