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A 419259

CAS No. : 364042-47-7

MCE 站：A 419259

产品活性：A 419259 是一种广谱的吡咯-嘧啶抑制剂，增强对 Src 家族的选择性，作用于 Src，Lck 和 Lyn，IC₅₀ 分别为 9 nM，<3 nM 和 <3 nM。

研究领域：Protein Tyrosine Kinase/RTK

作用靶点：Src

In Vitro: A 419259 is a second-generation pyrrolo-pyrimidine designed to enhance selectivity towards the Src family relative to other cytoplasmic tyrosine kinases. A-419259 inhibits K-562 cells with an IC₅₀ between 0.1 and 0.3 μM, and Meg-01 proliferation with an IC₅₀ of approximately 0.1 μM. A-419259 also potently induces apoptosis in K-562 cells beginning at 0.1 μM and increasing in a dose-dependent manner. PP2 inhibits Src kinase autophosphorylation in both Ph⁺ cell lines (K-562 and Meg-01) with an IC₅₀ between 3 and 10 μM, while A-419259 blocks kinase activation between 0.1 and 0.3 μM. A-419259 strongly inhibits DAGM/Bcr-Abl cell proliferation in the absence of IL-3 with an IC₅₀ between 0.1 and 0.3 μM. A-419259 is a broad-spectrum pyrrolo-pyrimidine inhibitor, and blocks proliferation and induces apoptosis in CML cell lines. A-419259 inhibits overall SFK activity in K562 and other CML cell lines with an IC₅₀ value of 0.1-0.3 μM.

相关产品：Bosutinib  |  PP2  |  SU6656  |  Src Inhibitor 1  |  WH-4-023  |  Pelitinib  |  Scutellarein  |  PP1  |  1-Naphthyl PP1  |  1-NM-PP1  |  Lck Inhibitor  |  RK-24466  |  Tolimidone  |  A-770041  |  PP121  |  PP58  |  PD173955  |  MNS  |  AZM475271  |  7-Hydroxy-4H-chromen-4-one  |  β-Hydroxyisovalerylshikonin  |  PD-161570  |  UM-164  |  CGP77675  |  Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH  |  Caffeic acid-pYEEIE TFA

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