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ATN-161

CAS No. : 262438-43-7

MCE 站：ATN-161

产品活性：ATN-161 (Ac-PHSCN-NH2)是一由纤连蛋白的协同区域衍生出的五氨基酸短肽；具有抗肿瘤活性的(beta)整合素拮抗剂。

研究领域：Cytoskeleton

作用靶点：Integrin

In Vitro: The combination of ATN-161 plus 5-FU significantly reduces tumor cell proliferation compared to control and single-agent therapy (p<0.01). In addition, combination therapy leads to a significant increase of apoptotic (TUNEL-positive) tumor cells (p<0.03), whereas single-agent therapy does not increase in TUNEL-positive tumor cells. ATN-161 treatment leads to a significant reduction in EC number (21% decrease) after a 48 hr incubation time compared to control (p<0.03). ATN-161 inhibites VEGF-induced migration and capillary tube formation in hCECs, but did not inhibit proliferation. ATN-161 decreases the number of cells migrating in response to VEGF in a dose-dependent manner starting at 100 nM (P<0.001 vs. VEGF group).

In Vivo: The preliminary experiments with α5β1-negative human colon cancer xenografts (HT29) show that treatment with ATN-161 significantly reduces tumor weight and vessel density. Injection of ATN-161 after laser photocoagulation inhibits choroidal neovascularization (CNV) leakage and neovascularization to an extent similar to AF564.

相关产品：Cilengitide  |  iRGD peptide  |  GLPG0187  |  MK-0429  |  E7820  |  ATN-161 trifluoroacetate salt  |  Cucurbitacin B  |  Leukadherin-1  |  RGD Trifluoroacetate  |  Arg-Gly-Asp-Ser  |  Eptifibatide  |  OSU-T315  |  A-205804  |  Cyclo(-RGDfK) TFA  |  RGD peptide (GRGDNP) (TFA)  |  Cyclo(RGDyK) trifluoroacetate  |  TR-14035  |  GRGDSP TFA  |  Tetrac  |  Tirofiban hydrochloride monohydrate  |  ILK-IN-3  |  BIO5192 hydrate  |  Natalizumab  |  Vedolizumab  |  α2β1 Integrin Ligand Peptide TFA  |  ICAM-1-IN-1  |  Zaurategrast ethyl ester  |  BIO5192  |  Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA

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