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Diclofenac potassium

CAS No. : 15307-81-0

MCE 站：Diclofenac potassium

产品活性：Diclofenac potassium 是一种有效的，非选择性抗炎剂，为 COX 的抑制剂，在 CHO 细胞中，对人 COX-1 和 COX-2 的 IC₅₀ 值分别为 4 和 1.3 nM。Diclofenac potassium 对绵羊 COX-1 和 COX-2 的 IC₅₀ 值分别为 5.1 μM，0.84 μM。Diclofenac potassium 通过活化 caspase 级联反应来诱导神经干细胞凋亡 (apoptosis)。

研究领域：Immunology/Inflammation  |  Apoptosis

作用靶点：COX  |  Apoptosis

In Vitro: Diclofenac effectively blocks COX-1 mediated prostanoid production from U937 cell microsomes, with an IC₅₀ of 7±3 nM.
Diclofenac (1-60 μM; 1 day) induces neural stem cells (NSCs) death in a concentration-dependent manner.
Diclofenac (10-60 μM; 6 hours) increases the expression of cleaved (activated) caspase-3.

In Vivo: Diclofenac (3 mg/kg, b.i.d., for 5 days) significantly increases faecal ⁵¹Cr excretion in rats, and such effect is also observed in squirrel monkeys after administrated of 1 mg/kg twice daily for 4 days.
Diclofenac (10 mg/kg; administered via oral route just prior to induction of inflammation) shows in vivo anti-inflammatory activity in Wistar rats.

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